ASSESSING VITAMIN E STATUS IN PARENTAL NUTRITION (PN) POPULATION IN ACCORDANCE TO ESPGHAN GUIDANCE: COMPARING SERUM VITAMIN E LEVELS TO VITAMIN E:CHOLESTEROL RATIO
Interesting study. Hopefully shows that you are maintaining good nutrition for your population!
Rulla Al-Araji
5 years ago
Good study of the current practice and explaining lab testing for vitamin E.
David Campbell
5 years ago
Thank you. I wonder if your Data suggests an even stronger relationship between those two variables, if the 8mmol/l cholesterol value were excluded i.e twice the upper limit of normal. I was not clear though what the rationale is for measuring the vitamin E:cholesterol ratio (or why ESPGHAN recommended a ratio rather than a plasma concentration alone? Do you know?
In the circulation Vit E is in lipoprotein particles (LDL in the main). When serum lipids are high therefore more Vit E circulates as it locates in the lipoprotein particles. When serum lipids are low, less VIt E circulates as there are less lipoprotein particles available for the VIt E to locate to. Expressing the Vit E:cholesterol ratio therefore gives a better measure of the VIt E status as high serum lipids may mask true Vit E deficiency and low serum lipids may mean a false impression of true Vit E deficiency is given.
Interesting study. Hopefully shows that you are maintaining good nutrition for your population!
Good study of the current practice and explaining lab testing for vitamin E.
Thank you. I wonder if your Data suggests an even stronger relationship between those two variables, if the 8mmol/l cholesterol value were excluded i.e twice the upper limit of normal. I was not clear though what the rationale is for measuring the vitamin E:cholesterol ratio (or why ESPGHAN recommended a ratio rather than a plasma concentration alone? Do you know?
In the circulation Vit E is in lipoprotein particles (LDL in the main). When serum lipids are high therefore more Vit E circulates as it locates in the lipoprotein particles. When serum lipids are low, less VIt E circulates as there are less lipoprotein particles available for the VIt E to locate to. Expressing the Vit E:cholesterol ratio therefore gives a better measure of the VIt E status as high serum lipids may mask true Vit E deficiency and low serum lipids may mean a false impression of true Vit E deficiency is given.
Thank you. Very helpful
Very clear and informative study. Important for our PN practice. Thank you