Thank you and I found this very interesting. You do not state what drug and what dose is administered. You mention what class of drug alone, does this imply you used a variety of drugs?
There are other drugs that act on PPARs, do they all have the same effect on bile synthesis?
Hi David, thank you for your interest. If you can have a look at methods, we gave Fenofibrate 10mg/kg OD. There are studies that compared various types of fibrates but mainly in animals not much in humans
Thank you and I found this very interesting. You do not state what drug and what dose is administered. You mention what class of drug alone, does this imply you used a variety of drugs?
There are other drugs that act on PPARs, do they all have the same effect on bile synthesis?
Hi David, thank you for your interest. If you can have a look at methods, we gave Fenofibrate 10mg/kg OD. There are studies that compared various types of fibrates but mainly in animals not much in humans
https://scholar.google.co.uk/scholar?q=fenofibrate+vs+bezafibrate+in+cholestasis&hl=en&as_sdt=0&as_vis=1&oi=scholart#d=gs_qabs&u=%23p%3DkuZz-JtZJsgJ
https://scholar.google.co.uk/scholar?q=fenofibrate+vs+bezafibrate+in+cholestasis&hl=en&as_sdt=0&as_vis=1&oi=scholart#d=gs_qabs&u=%23p%3D-XNAoiygZu4J
Thank you Huda, in deed I missed that, the dose was very helpful